Casein Kinase

Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (168)
Antibodies (5)
Casein Kinase Isoform Comparison

By Effects:	Ligand (1) Inhibitors (149) Degraders (5) Antagonist (1) Activator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-148251

MU1742		99.74%
MU1742 is a probe for CK1δ and CK1ε protein kinases.

HY-120084

BTX161	Inhibitor	99.20%
BTX161, a thalidomide analog, is an effective CKIα degrader. BTX161 mediates human AML cell CKIα degradation more effectively than lenalidomide and activates the DNA damage response (DDR) and p53, while stabilizing p53 antagonist MDM2.

HY-P3815

Casein Kinase 2 Substrate Peptide		98.47%
Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination.

HY-100114

TA-01	Inhibitor	99.86%
TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC₅₀s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.

HY-132175

CK2 inhibitor 2	Inhibitor	98.51%
CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC₅₀ of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC₅₀=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity.

HY-119751

Hematein	Inhibitor
Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC₅₀ of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells.

HY-110052

TBCA	Inhibitor	99.45%
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

HY-128677

NCC007	Inhibitor	99.73%
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC₅₀s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.

HY-123955

Casein Kinase inhibitor A86	Inhibitor	99.26%
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities.

HY-15704

LH846	Inhibitor	98.18%
LH846 is a selective inhibitor of CKIδ, with an IC₅₀ of 290 nM, and less potently inhibits CKIα and CKIε, with IC₅₀s of 2.5 μM and 1.3 μM, respectively.

HY-145320

TMX-4113	Inhibitor	99.08%
TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer.

HY-148491

CSNK1-IN-2	Inhibitor	98.20%
CSNK1-IN-2 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC₅₀ values of 2.52 μM. CSNK1-IN-2 can be used for the research of proliferative disorders.

HY-156816

ON 108600	Inhibitor	99.73%
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity.

HY-18285

Longdaysin	Inhibitor	99.83%
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC₅₀s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively.

HY-108606

PI-828	Inhibitor	99.62%
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

HY-159646

BMS-986397	Inhibitor

HY-153866

CK1-IN-2	Inhibitor	99.54%
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with an IC₅₀ values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.

HY-117857

MRT00033659	Inhibitor	99.77%
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC₅₀=0.9 μM for CK1δ) and CHK1 (IC₅₀=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.

HY-12279C

Umbralisib hydrochloride	Inhibitor	99.04%
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach.

HY-145260

BRD4/CK2-IN-1	Inhibitor	98.62%
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC₅₀s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)

Silmitasertib		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.94%
IWP-2	CK1δ, IC₅₀: 40 nM		99.93%
Emodin		CK2α Wild-type, IC₅₀: 5.9 μM (at ATP concentration is 50 μM) CK2α Wild-type, IC₅₀: 1.4 μM (at ATP concentration is 10 μM)	99.25%
Ellagic acid		CK2, IC₅₀: 40 nM	99.46%
CK1δ-IN-10	CK1δ, IC₅₀: 0.255 μM
QXG-6442	CK1α, DC₅₀: 5.7 nM
D4476	CK1, IC₅₀: 0.3 μM		99.94%
PF-670462 dihydrochloride	CKIδ, IC₅₀: 14 nM		99.96%
Silmitasertib sodium salt		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.92%
TBB		CK2, IC₅₀: 0.15 μM (Human CK2)	98.83%
TMX-4116	CK1α		99.76%
BTX-A51	CKIα		98.58%
FPFT-2216	CK1α		99.75%
SR-3029	CKIδ, IC₅₀: 44 nM		99.73%
PF-4800567	CKIδ, IC₅₀: 711 nM		99.69%
DMAT		CK2, IC₅₀: 0.13 μM (Human CK2)	98.09%
SGC-CK2-1		CK2α, IC₅₀: 36 nM CK2α', IC₅₀: 16 nM	99.67%
IC261	CKIδ, IC₅₀: 1 μM CkIα1, IC₅₀: 16 μM		99.54%
AMG-548 dihydrochloride	CK1		99.91%
TAK-715	CK1δ CK1ε		99.76%
PF-5006739	CK1δ, IC₅₀: 3.9 nM		99.56%
CKI-7 free base	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM		99.80%
BioE-1115		CK2α, IC₅₀: 10 μM	99.56%
LY294002 hydrochloride		CK2, IC₅₀: 0.098 μM CK2α2, IC₅₀: 3.869 μM	99.93%
CK2/ERK8-IN-1		CK2, IC₅₀: 0.5 μM CK2, Ki: 0.25 μM	≥99.0%
TTP 22		CK2, IC₅₀: 100 nM	98.40%
CK1-IN-1	CKIδ, IC₅₀: 15 nM		99.35%
MU1742	CKIδ		99.74%
Casein Kinase 2 Substrate Peptide		CK2	98.47%
TA-01	CKIδ, IC₅₀: 6.8 nM		99.86%
CK2 inhibitor 2		CK2, IC₅₀: 0.66 nM	98.51%
Hematein		CKII, IC₅₀: 0.74 μM
TBCA		CK2, IC₅₀: 110 nM CK2, Ki: 77 nM	99.45%
NCC007	CKIα, IC₅₀: 1.8 μM CKIδ, IC₅₀: 3.6 μM		99.73%
Casein Kinase inhibitor A86	CKIα		99.26%
LH846	CKIδ, IC₅₀: 290 nM CKIα, IC₅₀: 2.5 μM		98.18%
TMX-4113	CK1α		99.08%
ON 108600		CK2α2, IC₅₀: 0.005 μM CK2α1, IC₅₀: 0.05 μM	99.73%
Longdaysin	CKIα, IC₅₀: 5.6 μM CKIδ, IC₅₀: 8.8 μM		99.83%
PI-828		CK2, IC₅₀: 149 nM CK2α2, IC₅₀: 1.127 μM	99.62%
CK1-IN-2	CKIα, IC₅₀: 123 nM		99.54%
MRT00033659	CKIδ, IC₅₀: 0.9 μM		99.77%
BRD4/CK2-IN-1		CK2, IC₅₀: 230 nM	98.62%
Quinalizarin		CK2, Ki: ~50 nM CK2, IC₅₀: 110 nM
SRPIN803		CK2, IC₅₀: 203 nM	99.17%
AMG-548	CK1		≥99.0%
(R)-DRF053 dihydrochloride	CK1, IC₅₀: 14 nM		99.30%
A-3 hydrochloride	CK1, Ki: 80 μM	CK2, Ki: 5.1 μM	99.75%
Casein kinase 1δ-IN-1	CKIδ		99.91%
Casein kinase 1δ-IN-9	CK1δ		≥98.0%
IQA		CK2
Casein Kinase II Receptor Peptide		CK2, Km: 500 μM
CKI-7	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM
Casein kinase 1δ-IN-27	CK1ε, IC₅₀: 9.41 nM CK1δ, IC₅₀: 16.5 nM CK1α, IC₅₀: 22 nM
CK2-IN-3		CK2α, IC₅₀: 1.51 μM CK2α', IC₅₀: 7.64 μM
Ellagic acid (hydrate)		CK2, Ki: 20 nM CK2, IC₅₀: 40 nM
Casein kinase 1δ-IN-29	CKIδ, IC₅₀: 0.005 μM CK1ε, IC₅₀: 0.447 μM
Casein kinase 1δ-IN-4	CK1δ		≥98.0%
SR-4133	CK1ε, IC₅₀: 58 nM CK1δ, IC₅₀: 10 μM
CK2-IN-13		CK2, IC₅₀: 5.8 nM
Casein kinase 1δ-IN-3	CKIδ, pIC₅₀: 6.5376 M		99.93%
PIM-1/CK2-IN-2		CK2
Casein kinase 1δ-IN-10	CK1δ
MGD-28	CK1α, DC₅₀: 7.8 nM
TID43		CK2, IC₅₀: 0.3 μM
CK1-IN-3	CK1δ, IC₅₀: 2.22 μM		99.00%
CK2/PIM1-IN-1		CK2, IC₅₀: 3.787 μM
CK1-IN-4	CKIδ, IC₅₀: 2.74 μM
Casein kinase 1δ-IN-16	CKIδ
AMG-548 hydrochloride	CK1
SR-1277	CKIδ, IC₅₀: 49 nM
CK1δ-IN-3	CKIδ
Emodin (Standard)		CK2α Wild-type
CK2 inhibitor 4		CK2, IC₅₀: 3.8 μM
Casein kinase 1δ-IN-28	CK1ε, IC₅₀: 14.6 nM
EGFR-IN-57		CK2α, IC₅₀: 0.171 μM
Casein kinase 1δ-IN-15	CK1δ, IC₅₀: 0.045 μM
Multi-kinase-IN-6		CK2, IC₅₀: 0.09 μM
Casein kinase 1δ-IN-5	CK1δ, IC₅₀: 47 nM
Casein kinase 1δ-IN-17	CKIδ
Casein kinase 1δ-IN-18	CKIδ
HDAC/CK2-IN-1		CK2, IC₅₀: 3.67 μM
CK1δ-IN-9	CKIδ, IC₅₀: 1.4 nM
TMCB		CK2α, Ki: 83 nM CK2α', Ki: 21 nM
CK2 inhibitor 3		CK2, IC₅₀: 280 nM
Casein kinase 1δ-IN-31	CK1δ, IC₅₀: 17 nM CK1α, IC₅₀: 196 nM
p38α inhibitor 8	CK1δ, IC₅₀: 0.202 μM
4,5,6,7-Tetrabromo-1H-benzimidazole		CK2
CK2-IN-14		CK2, IC₅₀: 0.66 nM
CK2-IN-12		CK2, IC₅₀: 0.8 μM
WAY-606344	CK1δ
CSNK2-IN-2		CK2

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Casein Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (168)

Antibodies (5)

Casein Kinase Isoform Comparison

Casein Kinase Related Products (168):